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Berg and Shaw presented a cascade-testing algorithm that stratified patients first by total serum vitamin B 12 levels and second by MMA levels, using cutoffs of 118 pmol/L and 0.80 mol/L, respectively (Berg and Shaw, 2013)

Jasperson LK, Bucher C, Panoskaltsis-Mortari A, Mellor AL, Munn DH, Blazar BR

A molecular perspective on age-dependent changes to the heat shock axis

Multicomponent exercise not only improves physical fitnessincluding scores on the Short Physical Performance Battery (SPPB), a popular scale for measuring frailtybut also improves cognitive function after 24 months of exercise in older patients with diabetes and impaired lower-limb function [235]

Cost-effectiveness of age-related macular degeneration study supplements in the UK: combined trial and real-world outcomes data

In addition, the upregulation of hypoxia response is associated with an increase in the infiltration of activated inflammatory cells, accompanied by an increase in metabolic demand (59)